By Mariusz Z. Ratajczak
This well timed quantity explores a variety of recommendations for tissue and organ regeneration utilizing stem cells remoted from grownup tissues. It discusses substitute motives of stem cellphone plasticity in addition to present scientific effects with grownup stem mobile remedies. It examines the presence of power pluripotent stem cells in grownup tissues, paracrine results of stem mobilephone cures, and involvement of exosomes and microparticles into saw phenomena. Fifteen chapters, all written by way of famous leaders in their fields, concentrate on various themes together with wire blood and hematopoietic stem cells, dermis and tissue organ regeneration, very small embryonic-like stem cells, and mobilephone remedies in cardiology, neonatology, and neurology. Edited by means of Dr. Mariusz Ratajczak, an across the world identified expert in grownup stem mobilephone biology, Adult Stem telephone remedies: choices to Plasticity is a vital addition to the Stem phone Biology and Regenerative Medicine series.
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Additional info for Adult Stem Cell Therapies: Alternatives to Plasticity
Z. Ratajczak 75. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR et al (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418: 41–49 76. Jiang Y, Vaessen B, Lenvik T, Blackstad M, Reyes M, Verfaillie CM (2002) Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol 30:896–904 77. Kogler G, Sensken S, Airey JA, Trapp T, Muschen M, Feldhahn N et al (2004) A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential.
VEGF, FGF-2, or SDF-1). Third, we speculate that MVs derived from cells 28 M. Kucia et al. in hypoxic conditions would be enriched in mRNAs and miRNAs that promote angiogenesis. Furthermore, producer cell lines could be enriched for mRNA and regulatory miRNA species that, after delivery to the damaged tissues, would promote regeneration. Finally, we envision that MV producer cell lines could be enriched for molecules that facilitate their tropism to the damaged organ and subsequently promote retention of MVs in the damaged tissues.
Exp Hematol 34:914–925 108. Kucia M, Halasa M, Wysoczynski M, Baskiewicz-Masiuk M, Moldenhawer S, E Z-S (2007) Morphological and molecular characterization of novel population of CXCR4+SSEA4+Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report. Leukemia 21:297–303 Chapter 2 Novel Therapeutic Approaches in Regenerative Medicine—Adult Tissue-Derived Very Small Embryonic-like Stem Cells and Harnessing Paracrine Signals of Adult Stem Cells Magda Kucia, Malwina Suszynska, Janina Ratajczak and Mariusz Z.
Adult Stem Cell Therapies: Alternatives to Plasticity by Mariusz Z. Ratajczak