ABC Transporters: Biochemical, Cellular, and Molecular by John N. Abelson, Melvin I. Simon, Suresh V. Ambudkar, PDF

By John N. Abelson, Melvin I. Simon, Suresh V. Ambudkar, Michael M. Gottesman

ISBN-10: 0076687929

ISBN-13: 9780076687923

ISBN-10: 0121821935

ISBN-13: 9780121821937

The severely acclaimed laboratory regular for greater than 40 years, Methods in Enzymology is among the such a lot hugely revered guides within the box of biochemistry. on the grounds that 1955, every one quantity has been eagerly awaited, usually consulted, and praised by way of researchers and reviewers alike. greater than 285 volumes were released (all of them nonetheless in print) and masses of the fabric is proper even today-truly an important booklet for researchersin all fields of existence sciences.

Key Features
* Prokaryotic ABC Transporters
* Eukaryotic ABC Transporters
* Nonmammalian ABC delivery Systems
* Mammalian P-Glycoproteins
* Multidrug Resistance linked Protein
* Cystic Fibrosis Transmembrane Conductance Regulator
* Sulfonylurea Receptor
* Intracellular ABC Transporters

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Additional info for ABC Transporters: Biochemical, Cellular, and Molecular Aspects

Sample text

A. Treptow and H. A. Shuman, J. Mol. Biol. 202, 809 (1988). -I. Hor and H. A. Shuman, J. Mol. Biol. 233, 659 (1993). [11 BACTERIALABC TRANSPORTERS 13 ABC transporters, possibly their channel domains, and the helper proteins (see Table I) play no role in the specificityF Recently, random mutagenesis of helices 6, 7, and 8 of MalF was carried out by Ehrle et aL 58 Many mutations, clustered on one face of helix 6, changed the specificity of transport, again showing that the channel protein contributes to substrate specificity.

London), 326, 341 (1990). [ 11 BACTERIALABC TRANSPORTERS 11 A n interesting feature of MBP is its affinity not only to maltose but also to linear and cyclic maltodextrins. The crystal structure of the m a l t o s e - M B P complex shows a classical closed structure, 44 whereas the binding of/3cyclodextrin produces a largely open structure. 45 Interestingly, 3H N M R studies of ligand binding using maltose and maltodextrins labeled with 3H at C-1 showed that maltose binds to MBP in a way that involves a tight association of the reducing glucose moiety ("end-on mode"), whereas maltodextrins bind also in a way that does not involve the tight association of the reducing glucose residue ("middle mode").

3 C. F. Higgins, Annu. Rev. Cell Biol. 8, 67 (1992). 4 A. L. Davidson and H. Nikaido, J. Biol. Chem. 266, 8946 (1991). 5 N. A. Treptow and H. A. Shuman, J. Bacteriol. 163, 654 (1985). ~'D. A. Dean, L. I. Hor, H. A. Shuman, and H. Nikaido, Mol. Microbiol. 6, 2033 (1992). 7 j. A. Hall, J. L. Chen, and H. Nikaido, unpublished data (1995). s A. L. Davidson and H. Nikaido, J. Biol. Chem. 265, 4254 (1990). '~ S. V. Ambudkar and P. C. Maloney, Methods" Enzymol. 125, 558 (1986). 10 S. V. Ambudkar and P.

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ABC Transporters: Biochemical, Cellular, and Molecular Aspects by John N. Abelson, Melvin I. Simon, Suresh V. Ambudkar, Michael M. Gottesman


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